Structure | ![]() |
Cat No. | SBT1010 |
Product Name | Fostamatinib |
CAS No. | 901119-35-5 |
Molecular Formula | C23H26FN6O9P |
Molecular Weight | 580.46 |
Purity | 99% Min. |
Usage | Fostamatinib (R788)是活性代謝產(chǎn)物R406的前體藥物,是一種Syk抑制劑,IC50為41 nM,強(qiáng)效抑制Syk但不抑制Lyn,對(duì)Flt3作用效果低5倍。R788有效抑制體內(nèi)BCR信號(hào),導(dǎo)致惡性B細(xì)胞的增殖和存活減少,并顯著延長(zhǎng)治療組動(dòng)物的存活。在風(fēng)濕性關(guān)節(jié)炎模型Chemicalbook中,R788顯著減少主要炎癥介質(zhì),比如TNFalpha,IL-1,IL-6和IL-18,從而減少炎癥和骨退化。 |
Product Categories | APIs |